Anaesthesiology

Assessment of liver function by gadoxetic acid avidity in MRI in a model of rapid liver regeneration in rats.

Heil J, Augath M, Kurtcuoglu V, Hohmann J, Bechstein WO, Olthof P, Schnitzbauer AA, Seebeck P, Schiesser M, Schläpfer M, Beck-Schimmer B, Schadde E.HPB (Oxford). 2024 Apr;26(4):521-529. doi: 10.1016/j.hpb.2023.12.007. Epub 2023 Dec 21.PMID: 38185541

Functionalized magnetic nanoparticles remove donor-specific antibodies (DSA) from patient blood in a first ex vivo proof of principle study.

Lauener F, Schläpfer M, Mueller TF, Von Moos S, Janker S, Doswald S, Stark WJ, Beck-Schimmer B.Sci Rep. 2024 Jul 9;14(1):15818. doi: 10.1038/s41598-024-66876-3.PMID: 38982209

Sevoflurane Postconditioning Protects From an Early Neurological Deficit After Subarachnoid Hemorrhage: Results of a Randomized Laboratory Study in Rats.

Morax L, Beck-Schimmer B, Neff J, Mueller M, Flury-Frei R, Schläpfer M.Anesth Analg. 2024 Nov 1;139(5):1075-1085. doi: 10.1213/ANE.0000000000006829. Epub 2024 Oct 21.PMID: 39437202

Targeted Large-Volume Lymphocyte Removal Using Magnetic Nanoparticles in Blood Samples of Patients with Chronic Lymphocytic Leukemia: A Proof-of-Concept Study.

Janker S, Doswald S, Schimmer RR, Schanz U, Stark WJ, Schläpfer M, Beck-Schimmer B.Int J Mol Sci. 2023 Apr 19;24(8):7523. doi: 10.3390/ijms24087523.PMID: 37108680

Effects of sevoflurane and its metabolite hexafluoroisopropanol on hypoxia/reoxygenation-induced injury and mitochondrial bioenergetics in murine cardiomyocytes.

Roth Z'graggen B, Urner M, Beck-Schimmer B, Schläpfer M.BJA Open. 2022 Dec 30;5:100116. doi: 10.1016/j.bjao.2022.100116. eCollection 2023 Mar.PMID: 37587996

Removal of Circulating Tumor Cells from Blood Samples of Cancer Patients Using Highly Magnetic Nanoparticles: A Translational Research Project.

Doswald S, Herzog AF, Zeltner M, Zabel A, Pregernig A, Schläpfer M, Siebenhüner A, Stark WJ, Beck-Schimmer B.Pharmaceutics. 2022 Jul 1;14(7):1397. doi: 10.3390/pharmaceutics14071397.PMID: 35890293

Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junction protein beta catenin in a model of subarachnoid haemorrhage: A randomised animal study.

Beck-Schimmer B, Restin T, Muroi C, Roth Z'Graggen B, Keller E, Schläpfer M.Eur J Anaesthesiol. 2020 May;37(5):402-412. doi: 10.1097/EJA.0000000000001161.PMID: 32068571

Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration.

Dirscherl K, Schläpfer M, Roth Z'graggen B, Wenger RH, Booy C, Flury-Frei R, Fatzer R, Aloman C, Bartosch B, Parent R, Kurtcuoglu V, de Zélicourt D, Spahn DR, Beck Schimmer B, Schadde E.Sci Rep. 2020 Mar 9;10(1):4392. doi: 10.1038/s41598-020-60709-9.PMID: 3215232

Selection of publications of the last few years

Beck-Schimmer B, Restin T, Muroi C, Roth Z’Graggen B, Keller E, Schlaepfer M.
Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junctionprotein beta catenin in a model of subarachnoidhaemorrhage A randomised animal study.
Eur J Anaesthesiol 2020; 37:402–412

Beck-Schimmer B, Roth Z'graggen B; Booy C, Köppel S, Spahn, Donat R, Schläpfer M, Schadde E.
Sevoflurane Protects Hepatocytes From Ischemic Injury by Reducing Reactive Oxygen Species Signaling of Hepatic Stellate Cells: Translational Findings Based on a Clinical Trial.
Anesthesia and Analgesia 2018, 127(4):1058-1065.

Doswald S, Stark WJ, Beck-Schimmer B.
Biochemical functionality of magnetic particles as nanosensors: how far away are we to implement them into clinical practice?
J Nanobiotechnology 2019;17(1):73. Published 2019 May 31. doi:10.1186/s12951-019-0506-y

Dirscherl K, Schläpfer M, Roth Z’graggen B, Wenger RH, Booy C, Flury-Frei R, Fatzer R, Aloman C, Bartosch B, Parent R, Kurtcuoglu V, de Zélicourt D, Spahn DR, Beck Schimmer B, Schadde E
Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration.
Sci Rep 2020;10(1):4392. Published 2020 Mar 9. doi:10.1038/s41598-020-60709-9

Restin T, Kajdi ME, Schläpfer M, Roth Z'graggen B, Booy C, Dumrese C, Beck-Schimmer B
Sevoflurane protects rat brain endothelial barrier structure and function after hypoxia-reoxygenation injury
PLoS One, 2017 Oct 12;12(10):e0184973. doi: 10.1371/journal.pone.0184973. eCollection 2017.

Schadde E, Tsatsaris C, Swiderska-Syn M, Breitenstein S, Urner M, Schimmer R, Booy C, Z'graggen BR, Wenger RH, Spahn DR, Hertl M, Knechtle S, Diehl AM, Schläpfer M, Beck-Schimmer B
Hypoxia of the growing liver accelerates regeneration.
Surgery, 2017 Mar;161(3):666-679. doi: 10.1016/j.surg.2016.05.018. Epub 2016 Jul 16.

Kellner P, Müller M, Piegeler T, Eugster P, Booy C, Schläpfer M, Beck-Schimmer B
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Anesth Analg, 2017 Jan;124(1):194-203.

Beck-Schimmer B, Baumann L, Restin T, Eugster P, Hasler M, Booy C, Schläpfer M
Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study
Eur J Anaesthesiol, 2017 Nov; 34(11):764-775. doi: 10.1097/EJA.0000000000000668.

Jacobson M, Z’graggen B, Graber SM, Schumacher Ch, Stark WJ, Dumrese C, Mateos JM, Aemisegger C, Ziegler U, Urner M, Herrmann IK*, Beck-Schimmer B* (2015)
* shared senior authorship
Uptake of ferromagnetic carbon-encapsulated metal nanoparticles in dndothelial Cells: influence of shear stress and endothelial activation
Nanomedicine (Lond), 2015; 10:3537-46

Urner M, Schläpfer M, Herrmann IK, Hasler M, Schimmer RR, Booy C, Roth Z'graggen B, Rehrauer H, Aigner F, Minshall RD, Stark WJ, Beck-Schimmer B. (2015)
Insight into the beneficial immunomodulatory mechanism of the sevoflurane metabolite hexafluoro-2-propanol in a rat model of endotoxemia
Clin Exp Immunol. 181(3):468-79. doi: 10.1111/cei.12648.

Müller-Edenborn B, Frick R, Piegeler T, Schläpfer M, Roth-Z'graggen B, Schlicker A, Beck-Schimmer B. (2015)
Volatile anaesthetics reduce neutrophil inflammatory response by interferring with CXC receptor-2 signalling
Br J Anaesth. 114(1):143-9. doi: 10.1093/bja/aeu189.

Schläpfer M, Piegeler T, Dull RO, Schwartz DE, Mao M, Bonini MG, Z'graggen BR, Beck-Schimmer B, Minshall RD (2015)
Propofol increases morbidity and mortality in a rat model of sepsis
Crit Care., Feb 19;19(1):45. doi: 10.1186/s13054-015-0751-x

Urner M, Schlicker A, Z'graggen BR, Stepuk A, Booy C, Buehler KP, Limbach L, Chmiel C, Stark WJ, Beck-Schimmer B (2014)
Inflammatory response of lung macrophages and epithelial cells after exposure to redox active nanoparticles: effect of solubility and antioxidant tratment
Environ Sci Technol.,Dec 2;48(23):13960-8. doi: 10.1021/es504011m. Epub 2014 Nov 13

Herrmann IK, Schlegel A, Graf R, Schumacher CM, Senn N, Hasler M, Gschwind S, Hirt AM, Günther D, Clavien PA, Stark WJ, Beck-Schimmer B (2013)
Nanomagnet-based removal of lead and digoxin from living rats
Nanoscale, 5(18):8718-23

Herrmann IK, Castellon M, Schwartz DE, Hasler M, Urner M, Hu G, Minshall RD*, Beck-Schimmer B* (2013)
Intravenous application of a primary sevoflurane metabolite improves outcome in murine septic peritonitis: first results - (* shared senior authorship)
PLoS One, 8(8):e72057

Herrmann IK, Castellon M, Schwartz DE, Hasler M, Urner M, Hu G, Minshall RD, Beck-Schimmer B (2013)
Volatile anesthetics improve survival following cecal ligation and puncture
Anesthesiology, 119:901-6 (article with editorial)

Schläpfer M, Leutert AC, Voigtsberger S, Lachmann RA, Booy C, Beck-Schimmer B (2012)
Sevoflurane reduces severity of acute lung injury possibly by impariring formation of alveolar oedema
Clin Exp Immunol, 168:125-134

Müller-Edenborn B, Z’graggen B, Bartnicka K, Borgeat A, Hoos A, Borsig L, Beck-Schimmer B (2012)
Volatile anesthetics reduce invasion of colorectal cancer cells through downregulation of matrix metalloproteinase-9
Anesthesiology, 117:293-301

Urner M, Limbach LK, Herrmann IK, Müller-Edenborn B, Roth-Z'graggen B, Schlicker A, Reyes L, Booy C, Hasler M, Stark WJ*, Beck-Schimmer B* (2011) - (* shared senior authorship)
Fluorinated groups mediate the immunomodulatory effects of volatile anesthetics in acute cell injury
Am J Resp Cell Mol, 45:617-624

Herrmann IK, Martin Urner M, Hasler M, Roth-Z’Graggen B, Aemisegger C, Baulig W, Evagelos K. Athanassiou EK, Regenass S, Stark WJ*, Beck-Schimmer B* (2011) - (*shared senior authorship)
Iron core/shell nanoparticles as magnetic drug carriers: Possible interactions with the vascular compartment
Nanomedicine, 6:1199-1213

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