- Acid-base physiology: We aim to elucidate how systemic and local pH homeostasis is regulated and focus on mainly on the kidney.
- Physiology of renal transport systems contributing to the elimination of acid and transport of bicarbonate
- How does the kidney sense acidosis or changes in acid-base homeostasis. Role of proton-activated receptors and hormone systems regulated during acidosis.
- Adaptation of the kidney during acidosis in terms of morphology (plasticity of the collecting duct) and alterations in gene and protein expression and activity.
- Pathophysiology of renal acid-base transport: Genetic or pharmacologic mouse models mimicking inborn or acquired problems in renal acid-base transport
2. Regulation of epithelial phosphate transport (in close collaboration with the group of Jürg Biber)
- In vivo regulation of renal and intestinal phosphate transporters by hormones and phosphate
- Dysregulation of renal and intestinal phosphate transport in disease models
- Epithelial phosphate sensors: function, signaling, characterization, and identification