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Systemic acid-base homeostasis (i.e. pH and bicarbonate buffer concentrations of extracellular fluids) is essential for organ and cell function and results from complex interactions between different organs controlling and regulating this balance.
The kidney plays a central role maintaining and regulating bicarbonate, proton (pH), and electrolyte concentrations. This requires the coordinated action of various metabolic pathways (i.e. ammoniagenesis and bicarbonate generation) and transport processes such as Na+/H+-exchange, Na+-HCO3- -symport, Cl-/HCO3- -exchange, or H+-pumping. The activity of these pathways and processes is tightly regulated and adapted. Inborn or acquired diseases affect expression and regulation of these transport pathways and result in disturbed acid-base and electrolyte homeostasis.
Our current research focuses on four fields